Across TCGA patient cohorts, C4B mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C4B-associated genes across cancer lineages are ATM, VHL, and MIG-6. Each is linked with C4B in more than 1 cancer types. Because this analysis shows association rather than direction, both C4B-to-partner and partner-to-C4B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4B→partner) and Y-score (partner→C4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.759	-3.000	.003	.037	3	2
UCEC	VHL →	-1.035	-3.000	.008	.037	3	1
SKCM	MIG-6 →	+0.178	+2.832	.025	.034	3	1
SKCM	YAP_pS127 →	-0.387	-3.000	.030	.035	2	2
UCEC	mTOR_pS2448 →	-0.223	-3.000	.009	.037	1	2
SKCM	NF-kB-p65_pS536 →	-0.428	-3.000	.028	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

C4B survival (RNA) · tumor vs normal (RNA) · all C4B data types