C4A

Across TCGA pan-cancer cohorts, C4A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated C4A data layer compared with 21 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher C4A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated C4A expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where C4A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.862	1.000	.004	26	view →
CCRCC	DFS	Tertile	III,IV	0.765	0.396	.013	9	view →
LSCC	DFS	Median	All	0.887	0.976	.014	7	view →
HNSC	DFS	Tertile	III,IV	1.000	0.623	.040	2	view →
PDAC	OS	Tertile	III,IV	0.489	1.000	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

C4A–LUAD (OS)

Open the LUAD breakdown →