C4A

Across TCGA pan-cancer cohorts, C4A mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of C4A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where C4A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types C4A is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and LSCC are the cancer types where C4A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C4A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−1.208	<.001	11	view →
COAD	Male	III,IV	−0.838	<.001	10	view →
LSCC	Male	II,III,IV	−1.387	<.001	9	view →
LUAD	Female	II,III,IV	−0.939	<.001	9	view →
CCRCC	All	All	+0.337	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

C4A–HNSC

Open the HNSC breakdown →