C4A

Across TCGA patient cohorts, C4A RNA expression is significantly associated with the protein abundance of many other proteins, with 19,460 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible C4A-associated proteins across cancer lineages are CAVIN1_S118, CRIP2, and IMP4. Each is linked with C4A in more than 4 cancer types. Because this analysis shows association rather than direction, both C4A-to-partner and partner-to-C4A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C4A versus CAVIN1_S118 in BRCA, with a Pearson correlation of 0.55.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (C4A→partner) and Y-score (partner→C4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CAVIN1_S118 →	+1.067	+1.409	<.001	<.001	3	5
BRCA	CRIP2 →	+0.718	+1.910	<.001	<.001	3	5
BRCA	IMP4 →	-0.322	-1.916	<.001	<.001	3	5
BRCA	PLIN5_S140 →	+1.305	+1.098	<.001	.008	3	5
OV	RPL12 →	-0.192	-1.241	.001	<.001	3	5
LSCC	CLPX →	-0.254	-0.684	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,460 associations by consensus.

C4A vs CAVIN1_S118 — BRCA

Explore this scatter interactively →