C4A

Across TCGA patient cohorts, C4A protein abundance is significantly associated with the RNA expression of many other genes, with 12,220 significant associations in total. GBM shows the largest number of these associations.

The most reproducible C4A-associated genes across cancer lineages are SNAI1, CD93, and APLNR. Each is linked with C4A in more than 5 cancer types. Because this analysis shows association rather than direction, both C4A-to-partner and partner-to-C4A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C4A versus SNAI1 in OV, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4A→partner) and Y-score (partner→C4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SNAI1 →	+0.934	+0.780	.002	<.001	3	6
GBM	CD93 →	+1.111	+0.682	<.001	<.001	3	6
GBM	APLNR →	+1.028	+0.523	.003	.002	3	6
OV	SLIT3 →	+0.959	+0.629	.004	.002	3	6
COAD	SERPINE1 →	+1.413	+0.674	.004	.002	3	5
BRCA	LYVE1 →	+1.275	+0.852	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,220 associations by consensus.

C4A vs SNAI1 — OV

Explore this scatter interactively →