C4A

Across TCGA patient cohorts, C4A mutation is significantly associated with the RNA expression of many other genes, with 129 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C4A-associated genes across cancer lineages are SAR1AP3, DNAJB8-AS1, and MBD3L1. Each is linked with C4A in more than 1 cancer types. Because this analysis shows association rather than direction, both C4A-to-partner and partner-to-C4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAR1AP3 grouped by C4A-low versus C4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4A→partner) and Y-score (partner→C4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAR1AP3 →	+0.263	+3.424	<.001	<.001	3	2
SKCM	DNAJB8-AS1 →	+0.022	+3.809	<.001	.003	3	2
SKCM	MBD3L1 →	+0.045	+3.595	.001	.002	3	1
SKCM	C1orf167-AS1 →	+0.015	+4.265	<.001	.001	3	1
SKCM	RNU105C →	+0.078	+4.671	<.001	.004	3	1
SKCM	RNU6-1084P →	+0.155	+4.475	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 129 associations by consensus.

SAR1AP3 by C4A expression — UCEC

Explore this box plot interactively →