C4A

Across TCGA patient cohorts, C4A mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C4A-associated genes across cancer lineages are DC, pDC, and Th2 cells. Each is linked with C4A in more than 1 cancer types. Because this analysis shows association rather than direction, both C4A-to-partner and partner-to-C4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DC grouped by C4A-low versus C4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4A→partner) and Y-score (partner→C4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DC →	+0.045	+2.444	<.001	.026	3	1
UCEC	pDC →	+0.062	+2.815	.019	.036	2	1
UCEC	Th2 cells →	+0.318	+3.169	.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

DC by C4A expression — UCEC

Explore this box plot interactively →