Across TCGA patient cohorts, C3orf70 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C3orf70-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Cyclin-E2, and 14-3-3_beta. Each is linked with C3orf70 in more than 1 cancer types. Because this analysis shows association rather than direction, both C3orf70-to-partner and partner-to-C3orf70 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf70→partner) and Y-score (partner→C3orf70) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.435	-1.723	.005	.007	3	2
UCEC	Cyclin-E2 →	+0.174	+1.736	.002	.007	3	2
UCEC	14-3-3_beta →	-0.078	-1.973	.025	.029	3	1
UCEC	EGFR_pY1068 →	-0.263	-2.321	.002	.005	3	1
UCEC	eIF4E →	+0.219	+2.070	.002	.001	3	1
UCEC	eIF4G →	+0.309	+2.584	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Exploration

C3orf70 survival (RNA) · tumor vs normal (RNA) · all C3orf70 data types