C3orf38

Across TCGA pan-cancer cohorts, C3orf38 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated C3orf38 data layer compared with 30 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher C3orf38 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated C3orf38 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

UCEC, LSCC, and HNSC are the cancer types where C3orf38 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.595	1.000	.005	56	view →
LSCC	OS	Median	II,III,IV	0.688	0.967	.007	10	view →
HNSC	DFS	Tertile	III,IV	1.000	0.904	.016	9	view →
PDAC	DFS	Tertile	IV	0.934	0.250	.024	6	view →
GBM	DFS	Median	All	0.557	0.794	.010	4	view →
CCRCC	OS	Median	All	0.931	0.756	.012	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

C3orf38–UCEC (OS)

Open the UCEC breakdown →