C3orf38

Across TCGA patient cohorts, C3orf38 mutation is significantly associated with the RNA expression of many other genes, with 975 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C3orf38-associated genes across cancer lineages are LINC02722, MIR512-2, and SRXN1. Each is linked with C3orf38 in more than 1 cancer types. Because this analysis shows association rather than direction, both C3orf38-to-partner and partner-to-C3orf38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02722 grouped by C3orf38-low versus C3orf38-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf38→partner) and Y-score (partner→C3orf38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC02722 →	+0.044	+4.671	<.001	.004	3	2
HNSC	MIR512-2 →	+0.363	+7.954	<.001	.008	3	1
UCEC	SRXN1 →	+0.467	+3.343	.005	.005	3	1
UCEC	DGCR11 →	+0.606	+3.708	<.001	<.001	3	1
UCEC	PRAG1 →	+0.918	+3.732	<.001	<.001	3	1
UCEC	PRSS2 →	-1.453	-2.684	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 975 associations by consensus.

LINC02722 by C3orf38 expression — SKCM

Explore this box plot interactively →