C3orf38

Across TCGA patient cohorts, C3orf38 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C3orf38-associated genes across cancer lineages are IGFBP2, PREX1, and Annexin-1. Each is linked with C3orf38 in more than 1 cancer types. Because this analysis shows association rather than direction, both C3orf38-to-partner and partner-to-C3orf38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by C3orf38-low versus C3orf38-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf38→partner) and Y-score (partner→C3orf38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.672	-2.000	.021	.032	3	1
UCEC	PREX1 →	+0.270	+3.000	.029	.036	3	1
UCEC	Annexin-1 →	+0.532	+3.189	.024	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+0.919	+2.189	<.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

IGFBP2 by C3orf38 expression — UCEC

Explore this box plot interactively →