C3orf38

Across TCGA cell cohorts, C3orf38 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C3orf38-associated genes across cancer lineages are KRTAP12-3, DAZ4, and DAZ2. Each is linked with C3orf38 in more than 1 cancer types. Because this analysis shows association rather than direction, both C3orf38-to-partner and partner-to-C3orf38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP12-3 grouped by C3orf38-low versus C3orf38-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf38→partner) and Y-score (partner→C3orf38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KRTAP12-3 →	+0.124	+5.539	<.001	.003	3	1
LARGE_INTESTINE	DAZ4 →	+0.326	+4.977	<.001	.007	3	1
LARGE_INTESTINE	DAZ2 →	+0.336	+5.415	<.001	.004	3	1
LARGE_INTESTINE	RBMY1J →	+0.013	+6.022	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

KRTAP12-3 by C3orf38 expression — BLOOD_Leukemia

Explore this box plot interactively →