Across TCGA patient cohorts, C3orf35 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,952 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible C3orf35-associated proteins across cancer lineages are TOP2B, S100A8, and S100A9. Each is linked with C3orf35 in more than 5 cancer types. Because this analysis shows association rather than direction, both C3orf35-to-partner and partner-to-C3orf35 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf35→partner) and Y-score (partner→C3orf35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TOP2B →	+0.377	+0.469	<.001	<.001	3	6
PDAC	S100A8 →	-1.382	-0.340	<.001	.001	3	4
BRCA	S100A9 →	-1.185	-0.253	<.001	.003	3	4
GBM	HNRNPU →	+0.248	+0.298	.001	.007	2	5
LSCC	TOP2B_S1413 →	+0.570	+0.297	.001	.001	3	4
PDAC	STRN3 →	+0.231	+0.275	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,952 associations by consensus.

Exploration

C3orf35 survival (RNA) · tumor vs normal (RNA) · all C3orf35 data types