Across TCGA patient cohorts, C3orf35 mutation is significantly associated with the RNA expression of many other genes, with 399 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C3orf35-associated genes across cancer lineages are RN7SKP221, FXYD6P3, and RNU4-28P. Each is linked with C3orf35 in more than 1 cancer types. Because this analysis shows association rather than direction, both C3orf35-to-partner and partner-to-C3orf35 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf35→partner) and Y-score (partner→C3orf35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SKP221 →	+0.065	+7.471	<.001	.008	3	2
LUAD	FXYD6P3 →	+0.197	+6.584	<.001	.001	3	2
LUAD	RNU4-28P →	+0.325	+4.990	.003	.009	3	2
CESC	RN7SL813P →	+0.225	+5.103	<.001	.008	3	1
CESC	RN7SL655P →	+0.142	+5.418	<.001	.005	3	1
CESC	RNA5SP162 →	+0.771	+5.103	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 399 associations by consensus.

Exploration

C3orf35 survival (RNA) · tumor vs normal (RNA) · all C3orf35 data types