Across TCGA patient cohorts, C3orf35 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C3orf35-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and ERK2. Each is linked with C3orf35 in more than 1 cancer types. Because this analysis shows association rather than direction, both C3orf35-to-partner and partner-to-C3orf35 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf35→partner) and Y-score (partner→C3orf35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.134	-3.295	.003	.009	3	1
UCEC	EGFR_pY1068 →	-0.256	-2.000	.023	.032	3	1
UCEC	ERK2 →	+0.259	+3.584	.002	.002	3	1
UCEC	FOXO3a_pS318_S321 →	-0.148	-3.312	.008	.010	3	1
UCEC	GATA6 →	-0.233	-3.321	.001	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.239	-3.794	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

C3orf35 survival (RNA) · tumor vs normal (RNA) · all C3orf35 data types