C3orf33

Across TCGA patient cohorts, C3orf33 mutation is significantly associated with the RNA expression of many other genes, with 340 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C3orf33-associated genes across cancer lineages are RNU6-419P, ADM, and PRSS53. Each is linked with C3orf33 in more than 1 cancer types. Because this analysis shows association rather than direction, both C3orf33-to-partner and partner-to-C3orf33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-419P grouped by C3orf33-low versus C3orf33-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf33→partner) and Y-score (partner→C3orf33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-419P →	+0.749	+4.979	<.001	.009	3	2
UCEC	ADM →	+1.414	+3.595	<.001	.001	3	1
UCEC	PRSS53 →	+0.289	+3.254	.007	.008	3	1
UCEC	NCAPD3 →	+0.722	+3.329	.003	.005	3	1
UCEC	TMEM251 →	+0.626	+3.595	.005	.001	3	1
UCEC	ZNF18 →	+0.466	+3.617	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 340 associations by consensus.

RNU6-419P by C3orf33 expression — SKCM

Explore this box plot interactively →