C3orf33

Across TCGA patient cohorts, C3orf33 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C3orf33-associated genes across cancer lineages are JNK2, p70-S6K, and VHL. Each is linked with C3orf33 in more than 1 cancer types. Because this analysis shows association rather than direction, both C3orf33-to-partner and partner-to-C3orf33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by C3orf33-low versus C3orf33-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf33→partner) and Y-score (partner→C3orf33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.237	+3.321	.022	.010	3	1
UCEC	p70-S6K →	+0.205	+2.827	.042	.035	3	1
UCEC	VHL →	-1.073	-3.169	.002	.019	3	1
UCEC	CD20 →	+0.144	+3.321	.036	.010	3	1
UCEC	Chk2 →	-0.316	-3.000	.010	.036	2	1
UCEC	MEK1 →	+0.523	+3.321	.006	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

JNK2 by C3orf33 expression — UCEC

Explore this box plot interactively →