C3orf33

Across TCGA cell cohorts, C3orf33 mutation is significantly associated with the mutation status of many other genes, with 1,331 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible C3orf33-associated genes across cancer lineages are PDE9A, AQP3, and PRSS22. Each is linked with C3orf33 in more than 2 cancer types. Because this analysis shows association rather than direction, both C3orf33-to-partner and partner-to-C3orf33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDE9A grouped by C3orf33-low versus C3orf33-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf33→partner) and Y-score (partner→C3orf33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PDE9A →	+5.415	+5.415	.004	.004	1	3
OVARY	AQP3 →	+4.415	+4.977	.007	.007	1	3
OVARY	PRSS22 →	+4.415	+4.977	.007	.007	1	3
OVARY	MCCC1 →	+5.415	+5.415	.004	.004	1	3
LARGE_INTESTINE	ZNF491 →	+4.523	+5.087	.006	.006	1	3
OVARY	KIF20A →	+5.415	+5.415	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,331 associations by consensus.

PDE9A by C3orf33 expression — OVARY

Explore this box plot interactively →