C3orf22

Across TCGA pan-cancer cohorts, C3orf22 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated C3orf22 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher C3orf22 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated C3orf22 expression acts as an unfavorable survival marker.

LUSC, BRCA, and SKCM are the cancer types where C3orf22 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.178	0.743	.004	21	view →
BRCA	DFS	Median	All	0.321	0.903	.001	12	view →
SKCM	DFS	Median	All	0.505	0.731	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

C3orf22–LUSC (OS)

Open the LUSC breakdown →