C3orf20

Across TCGA patient cohorts, C3orf20 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,109 significant associations in total. STAD shows the largest number of these associations.

The most reproducible C3orf20-associated GO terms across cancer lineages are Negative regulation of protein-containing complex disassembly, Steroid hormone mediated signaling pathway, and Regulation of small GTPase mediated signal transduction. Each is linked with C3orf20 in more than 30 cancer types. Because this analysis shows association rather than direction, both C3orf20-to-partner and partner-to-C3orf20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein-containing complex disassembly grouped by C3orf20-low versus C3orf20-high in UCS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf20→partner) and Y-score (partner→C3orf20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	Negative regulation of protein-containing complex disassembly →	+0.060	+0.340	<.001	<.001	3	31
STAD	Steroid hormone mediated signaling pathway →	+0.065	+0.180	<.001	<.001	3	31
STAD	Regulation of small GTPase mediated signal transduction →	+0.063	+0.186	<.001	<.001	3	31
ESCA	Histone mRNA metabolic process →	+0.079	+0.374	<.001	<.001	3	31
THYM	Histone mRNA catabolic process →	+0.067	+0.189	<.001	<.001	3	31
STAD	Cytosolic transport →	+0.069	+0.207	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,109 associations by consensus.

Negative regulation of protein-containing complex disassembly by C3orf20 expression — UCS

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