C3orf20

Across TCGA patient cohorts, C3orf20 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C3orf20-associated genes across cancer lineages are 4E-BP1, eEF2, and eIF4E. Each is linked with C3orf20 in more than 2 cancer types. Because this analysis shows association rather than direction, both C3orf20-to-partner and partner-to-C3orf20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by C3orf20-low versus C3orf20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf20→partner) and Y-score (partner→C3orf20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.270	+3.700	.002	.001	3	3
SKCM	eEF2 →	+0.270	+1.678	.032	.022	3	2
UCEC	eIF4E →	+0.152	+2.713	.026	.003	3	2
UCEC	FoxM1 →	+0.230	+2.000	.006	<.001	3	2
UCEC	INPP4B →	-0.295	-3.087	.004	<.001	3	2
UCEC	MEK1 →	+0.332	+1.716	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

4E-BP1 by C3orf20 expression — UCEC

Explore this box plot interactively →