C3orf18

Across TCGA patient cohorts, C3orf18 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C3orf18-associated genes across cancer lineages are MAPK_pT202_Y204, MSH2, and mTOR_pS2448. Each is linked with C3orf18 in more than 1 cancer types. Because this analysis shows association rather than direction, both C3orf18-to-partner and partner-to-C3orf18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK_pT202_Y204 grouped by C3orf18-low versus C3orf18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf18→partner) and Y-score (partner→C3orf18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAPK_pT202_Y204 →	-0.480	-3.000	.034	.036	3	1
UCEC	MSH2 →	-0.398	-3.449	<.001	.005	3	1
UCEC	mTOR_pS2448 →	-0.179	-2.459	.012	.020	3	1
UCEC	Notch1 →	+0.173	+2.459	.011	.020	3	1
UCEC	p70-S6K_pT389 →	-0.201	-2.990	.029	.036	3	1
UCEC	PKC-b-II_pS660 →	-0.270	-2.459	.043	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MAPK_pT202_Y204 by C3orf18 expression — UCEC

Explore this box plot interactively →