C3orf18

Across TCGA cell cohorts, C3orf18 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,678 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible C3orf18-associated GO terms across cancer lineages are Actin filament depolymerization, Regulation of focal adhesion assembly, and Regulation of cell-substrate junction assembly. Each is linked with C3orf18 in more than 13 cancer types. Because this analysis shows association rather than direction, both C3orf18-to-partner and partner-to-C3orf18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament depolymerization grouped by C3orf18-low versus C3orf18-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf18→partner) and Y-score (partner→C3orf18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Actin filament depolymerization →	+0.225	+2.123	<.001	<.001	3	14
PANCREAS	Regulation of focal adhesion assembly →	+0.089	+1.500	<.001	<.001	3	12
PANCREAS	Regulation of cell-substrate junction assembly →	+0.089	+1.500	<.001	<.001	3	12
BONE	Positive regulation of focal adhesion assembly →	+0.208	+1.256	.001	.008	3	11
SOFT_TISSUE	Positive regulation of cell-substrate junction organization →	+0.111	+1.383	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Macroautophagy →	+0.085	+1.785	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,678 associations by consensus.

Actin filament depolymerization by C3orf18 expression — LIVER

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