C3orf14

Across TCGA patient cohorts, C3orf14 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C3orf14-associated genes across cancer lineages are IGFBP2, Annexin-1, and VHL. Each is linked with C3orf14 in more than 1 cancer types. Because this analysis shows association rather than direction, both C3orf14-to-partner and partner-to-C3orf14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by C3orf14-low versus C3orf14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf14→partner) and Y-score (partner→C3orf14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.819	-3.169	.021	.020	3	1
UCEC	Annexin-1 →	+0.683	+3.169	.018	.020	3	1
UCEC	VHL →	-1.165	-3.000	.001	.036	3	1
UCEC	PKC-a_pS657 →	+0.489	+3.183	.019	.010	2	1
UCEC	Caspase-8 →	-0.331	-3.169	.016	.019	2	1
UCEC	Rab25 →	-0.555	-3.169	.002	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

IGFBP2 by C3orf14 expression — UCEC

Explore this box plot interactively →