C3AR1

Across TCGA pan-cancer cohorts, C3AR1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated C3AR1 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher C3AR1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated C3AR1 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LUAD, PDAC, and LSCC are the cancer types where C3AR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.995	0.540	.014	12	view →
PDAC	OS	Quartile	III,IV	0.250	0.850	.038	6	view →
LSCC	DFS	Median	II,III,IV	0.575	0.861	.008	5	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

C3AR1–LUAD (DFS)

Open the LUAD breakdown →