C3AR1

Across TCGA patient cohorts, C3AR1 mutation is significantly associated with the RNA expression of many other genes, with 1,834 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C3AR1-associated genes across cancer lineages are DSCR8, RNU1-105P, and RNU6-781P. Each is linked with C3AR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both C3AR1-to-partner and partner-to-C3AR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DSCR8 grouped by C3AR1-low versus C3AR1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3AR1→partner) and Y-score (partner→C3AR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	DSCR8 →	+1.423	+3.909	.001	.007	3	3
LUSC	RNU1-105P →	+0.178	+4.309	<.001	.007	3	3
UCEC	RNU6-781P →	+0.288	+1.949	<.001	.005	3	3
BRCA	RNU6-830P →	+0.252	+8.471	<.001	.005	3	2
READ	RNU6-937P →	+0.709	+4.142	<.001	.004	3	2
READ	OR12D1 →	+0.064	+4.672	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,834 associations by consensus.

DSCR8 by C3AR1 expression — READ

Explore this box plot interactively →