C3AR1

Across TCGA patient cohorts, C3AR1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C3AR1-associated genes across cancer lineages are Notch1, FoxM1, and Lck. Each is linked with C3AR1 in more than 3 cancer types. Because this analysis shows association rather than direction, both C3AR1-to-partner and partner-to-C3AR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by C3AR1-low versus C3AR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3AR1→partner) and Y-score (partner→C3AR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.166	+2.183	.004	.033	3	4
UCEC	FoxM1 →	+0.265	+2.331	.013	.019	3	2
UCEC	Lck →	+0.182	+3.000	.028	.036	3	2
UCEC	p27_pT198 →	+0.119	+1.807	.007	.027	3	2
UCEC	p62 Lck ligand →	+0.433	+2.594	.001	.006	3	2
UCEC	RAD51 →	+0.144	+2.584	.012	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Notch1 by C3AR1 expression — UCEC

Explore this box plot interactively →