C3AR1

Across TCGA cell cohorts, C3AR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,492 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible C3AR1-associated GO terms across cancer lineages are Positive regulation of focal adhesion assembly, Positive regulation of extracellular matrix organization, and Regulation of protein localization to mitochondrion. Each is linked with C3AR1 in more than 10 cancer types. Because this analysis shows association rather than direction, both C3AR1-to-partner and partner-to-C3AR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of focal adhesion assembly grouped by C3AR1-low versus C3AR1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C3AR1→partner) and Y-score (partner→C3AR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of focal adhesion assembly →	+0.118	+0.172	.002	.009	3	10
SOFT_TISSUE	Positive regulation of extracellular matrix organization →	+0.126	+0.657	<.001	.007	2	11
SOFT_TISSUE	Regulation of protein localization to mitochondrion →	+0.114	+1.060	<.001	<.001	3	10
BREAST	Urokinase plasminogen activator signaling pathway →	+1.108	+0.197	<.001	.005	3	10
KIDNEY	Collagen biosynthetic process →	+0.193	+0.868	<.001	.001	3	10
PANCREAS	Regulation of focal adhesion assembly →	+0.071	+0.182	<.001	.007	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,492 associations by consensus.

Positive regulation of focal adhesion assembly by C3AR1 expression — BREAST

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