C3AR1

Across TCGA cell cohorts, C3AR1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C3AR1-associated genes across cancer lineages are ASZ1, CALHM4, and PROP1. Each is linked with C3AR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both C3AR1-to-partner and partner-to-C3AR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASZ1 grouped by C3AR1-low versus C3AR1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3AR1→partner) and Y-score (partner→C3AR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASZ1 →	+0.119	+4.152	.001	.009	3	1
BLOOD_Leukemia	CALHM4 →	+0.038	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	PROP1 →	+0.032	+4.874	<.001	.002	3	1
BLOOD_Leukemia	OR1D4 →	+0.046	+4.539	<.001	.007	3	1
SKIN	KRT71 →	+0.024	+4.977	.004	.007	3	1
SKIN	IFNL3 →	+0.052	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ASZ1 by C3AR1 expression — BLOOD_Leukemia

Explore this box plot interactively →