C3

Across TCGA pan-cancer cohorts, C3 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of C3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where C3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types C3 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and LUAD are the cancer types where C3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.888	<.001	12	view →
HNSC	Male	IV	−1.297	<.001	11	view →
LUAD	Female	III,IV	−1.372	<.001	9	view →
LSCC	Male	All	−1.354	<.001	9	view →
PDAC	Female	All	+0.597	<.001	5	view →
OV	All	All	−0.789	.019	2	view →
CCRCC	All	All	+0.242	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

C3–COAD

Open the COAD breakdown →