C3

Across TCGA patient cohorts, C3 RNA expression is significantly associated with the protein abundance of many other proteins, with 23,917 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible C3-associated proteins across cancer lineages are MNDA, ARHGAP30, and ITGAL. Each is linked with C3 in more than 7 cancer types. Because this analysis shows association rather than direction, both C3-to-partner and partner-to-C3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C3 versus MNDA in GBM, with a Pearson correlation of 0.57.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (C3→partner) and Y-score (partner→C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MNDA →	+0.923	+0.993	<.001	<.001	3	8
GBM	ARHGAP30 →	+0.748	+1.312	<.001	<.001	3	8
GBM	ITGAL →	+0.625	+1.358	<.001	<.001	3	7
GBM	MYO1G →	+0.809	+1.210	<.001	<.001	3	7
OV	ACAP1_T739 →	+0.843	+1.925	.002	.002	3	7
GBM	ARHGAP9 →	+0.580	+1.183	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,917 associations by consensus.

C3 vs MNDA — GBM

Explore this scatter interactively →