C3

Across TCGA patient cohorts, C3 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C3-associated genes across cancer lineages are Cyclin-E2, Cyclin-B1, and STAT3_pY705. Each is linked with C3 in more than 3 cancer types. Because this analysis shows association rather than direction, both C3-to-partner and partner-to-C3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by C3-low versus C3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3→partner) and Y-score (partner→C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.116	+1.180	.008	.005	3	4
UCEC	Cyclin-B1 →	+0.664	+1.963	<.001	<.001	3	3
UCEC	STAT3_pY705 →	-0.323	-1.637	<.001	<.001	3	3
BLCA	4E-BP1 →	+0.292	+2.187	.021	.034	3	2
STAD	FASN →	+0.412	+3.015	.022	.018	3	2
COAD	TSC1 →	-0.451	-3.161	<.001	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Cyclin-E2 by C3 expression — UCEC

Explore this box plot interactively →