C3

Across TCGA cell cohorts, C3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,140 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible C3-associated GO terms across cancer lineages are Vertebrate eye-specific patterning, Complement activation, GZMK pathway, and Opsonization. Each is linked with C3 in more than 18 cancer types. Because this analysis shows association rather than direction, both C3-to-partner and partner-to-C3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vertebrate eye-specific patterning grouped by C3-low versus C3-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C3→partner) and Y-score (partner→C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Vertebrate eye-specific patterning →	+2.059	+4.534	<.001	<.001	3	19
OESOPHAGUS	Complement activation, GZMK pathway →	+1.996	+4.193	<.001	<.001	3	19
URINARY_TRACT	Opsonization →	+2.165	+4.876	<.001	<.001	3	19
LUNG_NSCLC_LUAD	Complement-mediated synapse pruning →	+2.197	+4.534	<.001	<.001	3	18
LIVER	Complement activation, classical pathway →	+1.804	+5.407	<.001	<.001	3	18
LIVER	Complement activation, lectin pathway →	+2.228	+5.725	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,140 associations by consensus.

Vertebrate eye-specific patterning by C3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →