C3

Across TCGA cell cohorts, C3 mutation is significantly associated with the RNA expression of many other genes, with 1,665 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C3-associated genes across cancer lineages are KRT73, IQCF5, and TARM1. Each is linked with C3 in more than 2 cancer types. Because this analysis shows association rather than direction, both C3-to-partner and partner-to-C3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT73 grouped by C3-low versus C3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3→partner) and Y-score (partner→C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KRT73 →	+1.057	+3.491	.007	.009	3	3
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.056	+5.357	<.001	.003	3	3
URINARY_TRACT	TARM1 →	+0.020	+4.087	<.001	.009	3	2
KIDNEY	TBXT →	+0.020	+5.000	<.001	.005	3	2
OESOPHAGUS	IDI2 →	+0.020	+3.273	<.001	.004	3	2
BLOOD_Leukemia	UNC45B →	+0.194	+3.408	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,665 associations by consensus.

KRT73 by C3 expression — BLOOD_Leukemia

Explore this box plot interactively →