C3

Across TCGA cell cohorts, C3 mutation is significantly associated with the mutation status of many other genes, with 7,022 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C3-associated genes across cancer lineages are CACNA1H, SALL4, and FSIP2. Each is linked with C3 in more than 7 cancer types. Because this analysis shows association rather than direction, both C3-to-partner and partner-to-C3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CACNA1H grouped by C3-low versus C3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3→partner) and Y-score (partner→C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CACNA1H →	+2.925	+2.925	<.001	<.001	1	8
LUNG_NSCLC_LUAD	SALL4 →	+3.662	+3.000	.007	.007	1	7
OVARY	FSIP2 →	+2.877	+4.639	<.001	<.001	1	7
CNS	PREX2 →	+3.584	+3.762	.003	.003	1	7
CNS	ZNF592 →	+5.000	+5.000	<.001	<.001	1	6
KIDNEY	SIPA1L2 →	+5.000	+5.000	.006	.006	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,022 associations by consensus.

CACNA1H by C3 expression — LARGE_INTESTINE

Explore this box plot interactively →