Across TCGA pan-cancer cohorts, C2orf92 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of C2orf92’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where C2orf92 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C2orf92 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.
KIRC, KICH, and LIHC are the cancer types where C2orf92 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C2orf92 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.