Across TCGA pan-cancer cohorts, C2orf76 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated C2orf76 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher C2orf76 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated C2orf76 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where C2orf76 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.971	0.576	<.001	36	view →
CCRCC	DFS	Tertile	All	0.562	0.883	.010	18	view →
PDAC	DFS	Tertile	III,IV	0.742	0.383	.039	2	view →
LSCC	OS	Quartile	II,III,IV	0.991	0.697	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: C2orf76 tumor-vs-normal RNA expression · all C2orf76 data types