C2orf73

Across TCGA pan-cancer cohorts, C2orf73 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated C2orf73 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher C2orf73 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated C2orf73 expression acts as an unfavorable survival marker.

ESCA, COAD, and HNSC are the cancer types where C2orf73 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.130	0.703	<.001	24	view →
COAD	OS	Median	All	0.273	0.803	.005	15	view →
HNSC	OS	Median	All	0.166	0.751	.009	12	view →
PCPG	DFS	Median	All	0.086	0.768	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

C2orf73–ESCA (OS)

Open the ESCA breakdown →