C2orf73

Across TCGA patient cohorts, C2orf73 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C2orf73-associated genes across cancer lineages are A-Raf_pS299, FoxM1, and FOXO3a_pS318_S321. Each is linked with C2orf73 in more than 1 cancer types. Because this analysis shows association rather than direction, both C2orf73-to-partner and partner-to-C2orf73 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by C2orf73-low versus C2orf73-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2orf73→partner) and Y-score (partner→C2orf73) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.136	-2.459	.009	.019	3	1
UCEC	FoxM1 →	+0.318	+2.115	.004	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.111	-2.449	.042	.019	3	1
UCEC	Ku80 →	+0.269	+2.128	.009	.010	3	1
UCEC	MEK1 →	+0.604	+3.584	<.001	.002	3	1
UCEC	mTOR_pS2448 →	-0.155	-3.156	.017	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

A-Raf_pS299 by C2orf73 expression — UCEC

Explore this box plot interactively →