C2orf73

Across TCGA cell cohorts, C2orf73 mutation is significantly associated with the mutation status of many other genes, with 575 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C2orf73-associated genes across cancer lineages are MCM4, RAB11FIP3, and RNF31. Each is linked with C2orf73 in more than 2 cancer types. Because this analysis shows association rather than direction, both C2orf73-to-partner and partner-to-C2orf73 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCM4 grouped by C2orf73-low versus C2orf73-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2orf73→partner) and Y-score (partner→C2orf73) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MCM4 →	+5.415	+5.415	.004	.004	1	3
OVARY	RAB11FIP3 →	+4.415	+4.977	.007	.007	1	2
LARGE_INTESTINE	RNF31 →	+3.350	+4.584	.003	.003	1	2
OVARY	PARP10 →	+5.415	+5.415	.004	.004	1	2
OVARY	NUGGC →	+4.415	+4.977	.007	.007	1	2
LARGE_INTESTINE	MSC →	+3.350	+4.584	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 575 associations by consensus.

MCM4 by C2orf73 expression — OVARY

Explore this box plot interactively →