Across TCGA pan-cancer cohorts, C2orf72 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of C2orf72’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where C2orf72 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types C2orf72 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

COAD and LUAD are the cancer types where C2orf72 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C2orf72 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.869	<.001	9	view →
LUAD	All	All	+0.695	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: C2orf72 RNA expression & survival · all C2orf72 data types