C2orf69

Across TCGA pan-cancer cohorts, C2orf69 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated C2orf69 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher C2orf69 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated C2orf69 expression acts as an unfavorable survival marker, although some lineages such as GBM and UCEC show a favorable association.

CCRCC, LUAD, and GBM are the cancer types where C2orf69 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.397	0.759	.006	27	view →
LUAD	DFS	Quartile	All	0.669	0.902	.005	26	view →
GBM	DFS	Median	All	0.818	0.623	<.001	13	view →
UCEC	DFS	Quartile	II,III,IV	1.000	0.445	.018	8	view →
PDAC	OS	Quartile	II,III,IV	0.865	1.000	.032	5	view →
HNSC	OS	Median	III,IV	0.787	0.939	.003	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

C2orf69–CCRCC (DFS)

Open the CCRCC breakdown →