C2orf69

Across TCGA pan-cancer cohorts, C2orf69 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of C2orf69’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where C2orf69 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types C2orf69 is over-expressed in tumor, although a few such as PDAC and CCRCC show the opposite, repressed pattern.

LSCC, PDAC, and CCRCC are the cancer types where C2orf69 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C2orf69 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Female	All	+0.344	<.001	9	view →
PDAC	Female	II,III,IV	−0.546	<.001	7	view →
CCRCC	Male	All	−0.342	<.001	7	view →
COAD	Male	All	−0.256	.003	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

C2orf69–LSCC

Open the LSCC breakdown →