C2orf69

Across TCGA patient cohorts, C2orf69 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C2orf69-associated genes across cancer lineages are ERK2, JNK2, and MSH2. Each is linked with C2orf69 in more than 1 cancer types. Because this analysis shows association rather than direction, both C2orf69-to-partner and partner-to-C2orf69 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by C2orf69-low versus C2orf69-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2orf69→partner) and Y-score (partner→C2orf69) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.207	+2.321	.032	.035	3	1
UCEC	JNK2 →	+0.241	+2.321	.016	.035	3	1
UCEC	MSH2 →	-0.313	-2.321	.006	.035	3	1
UCEC	p62 Lck ligand →	+0.332	+2.817	.042	.036	3	1
UCEC	STAT3_pY705 →	-0.418	-2.321	.001	.035	3	1
UCEC	ASNS →	+0.579	+2.321	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ERK2 by C2orf69 expression — UCEC

Explore this box plot interactively →