C2orf42

Across TCGA patient cohorts, C2orf42 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C2orf42-associated genes across cancer lineages are EGFR_pY1068, eIF4G, and JNK_pT183_Y185. Each is linked with C2orf42 in more than 1 cancer types. Because this analysis shows association rather than direction, both C2orf42-to-partner and partner-to-C2orf42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by C2orf42-low versus C2orf42-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2orf42→partner) and Y-score (partner→C2orf42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.291	-3.459	.006	.005	3	1
UCEC	eIF4G →	+0.349	+3.169	.008	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.211	-3.700	.003	.001	3	1
UCEC	JNK2 →	+0.198	+3.179	.018	.010	3	1
UCEC	MEK1 →	+0.381	+2.906	.014	.001	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.563	-2.321	.003	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

EGFR_pY1068 by C2orf42 expression — UCEC

Explore this box plot interactively →