C2orf15

Across TCGA pan-cancer cohorts, C2orf15 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated C2orf15 data layer compared with 2 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher C2orf15 RNA is associated with better overall survival. In most high-consensus cancer types, elevated C2orf15 expression acts as an unfavorable survival marker, although some lineages such as BRCA and HNSC show a favorable association.

BRCA, HNSC, and READ are the cancer types where C2orf15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Quartile	IV	0.844	0.183	.008	67	view →
HNSC	OS	Median	IV	0.774	0.637	.004	46	view →
READ	OS	Median	II,III,IV	0.972	0.852	.004	41	view →
KIRP	DFS	Median	IV	0.036	0.528	.001	36	view →
OV	OS	Median	All	0.869	0.811	.012	22	view →
UCS	DFS	Tertile	III,IV	0.195	0.526	.028	18	view →
KICH	DFS	Median	II,III,IV	0.602	0.910	.013	16	view →
LIHC	DFS	Quartile	III,IV	0.153	0.390	.005	15	view →
UVM	DFS	Quartile	III,IV	0.328	0.900	.018	13	view →
LGG	OS	Median	All	0.868	0.917	.012	13	view →
MESO	OS	Median	II,III,IV	0.369	0.208	.026	12	view →
KIRC	DFS	Tertile	II,III,IV	0.609	0.399	.006	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

C2orf15–BRCA (OS)

Open the BRCA breakdown →