C2CD5

Across TCGA pan-cancer cohorts, C2CD5 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of C2CD5’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where C2CD5 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types C2CD5 is over-expressed in tumor, although a few such as CCRCC and LUAD show the opposite, repressed pattern.

CCRCC, LUAD, and LSCC are the cancer types where C2CD5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C2CD5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	All	−0.130	<.001	10	view →
LUAD	Female	II,III,IV	−0.150	<.001	3	view →
LSCC	Female	II,III,IV	−0.160	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

C2CD5–CCRCC

Open the CCRCC breakdown →