C2CD4C

Across TCGA pan-cancer cohorts, C2CD4C mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of C2CD4C’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where C2CD4C mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types C2CD4C is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD and CCRCC are the cancer types where C2CD4C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C2CD4C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	−1.091	<.001	9	view →
CCRCC	Male	All	−0.275	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

C2CD4C–COAD

Open the COAD breakdown →