Across TCGA patient cohorts, C2CD4A mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C2CD4A-associated genes across cancer lineages are eIF4E, TFRC, and Bax. Each is linked with C2CD4A in more than 1 cancer types. Because this analysis shows association rather than direction, both C2CD4A-to-partner and partner-to-C2CD4A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2CD4A→partner) and Y-score (partner→C2CD4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.237	+3.335	.008	.005	3	2
UCEC	TFRC →	+0.737	+3.169	.001	.018	3	2
UCEC	Bax →	+0.246	+2.222	.015	.011	3	2
UCEC	eEF2 →	+0.381	+2.999	.012	.035	3	1
UCEC	EGFR_pY1068 →	-0.388	-2.906	<.001	.001	3	1
UCEC	A-Raf_pS299 →	-0.156	-2.459	.002	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

C2CD4A survival (RNA) · tumor vs normal (RNA) · all C2CD4A data types