C2CD3

Across TCGA patient cohorts, C2CD3 mutation is significantly associated with the RNA expression of many other genes, with 5,539 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C2CD3-associated genes across cancer lineages are HJURP, KIF2C, and ATF4. Each is linked with C2CD3 in more than 3 cancer types. Because this analysis shows association rather than direction, both C2CD3-to-partner and partner-to-C2CD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HJURP grouped by C2CD3-low versus C2CD3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C2CD3→partner) and Y-score (partner→C2CD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HJURP →	+0.921	+2.584	.001	.001	3	4
LUAD	KIF2C →	+0.863	+2.700	.002	.006	3	4
UCEC	ATF4 →	+0.523	+2.447	<.001	<.001	3	4
UCEC	CORO2B →	-0.531	-3.159	.001	<.001	3	4
STAD	ACYP1 →	+0.529	+2.750	.003	.003	3	4
UCEC	PSMC3IP →	+0.771	+2.425	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,539 associations by consensus.

HJURP by C2CD3 expression — LUAD

Explore this box plot interactively →